产品货号：
Z22633
中文名称：
NT5DC3抗体
英文名称：
Anti-NT5DC3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NT5DC3 Antibody |
| 指标别名 | GRP94-neighboring nucleotidase;NT5DC3;GNN;TU12B1-TY;TU12B1TY |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM(Intracellular),ELISA |
| 基因名称 | NT5DC3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human NT5DC3 recombinant protein (Position:D52-K548). |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | 5’-Nucleotidase domain containing 2 (NT5DC2) is a member of the NT5DC family and contains a haloacid dehalogenase motif localized in the N-terminus of these proteins.NT5DC2 shows high sequence similarity with NT5C2.NT5C2 has received attention in the field of hematological neoplasms because NT5C2 mutations have been demonstrated to drive resistance to thiopurine,a drug frequently used to treat hematological neoplasms.NT5C2 catalyzes purine-nucleotide metabolism and induces chemotherapeutic resistance via excess export of purines to the extracellular space and depletion of the intracellular purine-nucleotide pool.Therefore,NT5DC2 may also participate in purine-nucleotide metabolism and exert purine-nucleotide catalytic activity.NT5DC2 overexpression promotes HCC cell proliferation and clone formation by regulating the cell cycle and promoting tumor growth in subcutaneous xenografts,while NT5DC2 knockdown inhibits these processes.NT5DC2 is associated with attention-deficit/hyperactivity disorder and bipolar disorder.NT5DC2 interacts with tyrosine hydroxylase (TH) to regulate TH catalytic activity and thus regulate catecholamine synthesis.NT5DC2 has been shown to interact with and stabilize Fyn,an Src family proto-oncogene,and plays a role in regulating glioblastoma progression. |
| Uniprot ID | Q86UY8 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | 5'-nucleotidase domain containing 3 |
| 蛋白名全称 | 5'-nucleotidase domain-containing protein 3 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Flow Cytometry(Intracellular) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 |
| Gene ID | 4913 |
相关搜索：NT5DC3抗体，NT5DC3多抗，Anti-NT5DC3 Antibody